11 ADVATE potencies allow for flexible dosing options1,2

ADVATE has more single-dose infusion options than any other factor VIII product.†1,2

Image of 2 mL and 5 mL vials and their associated dosing options. Image of 2 mL and 5 mL vials and their associated dosing options.

As of August 2019.

ADVATE in a BAXJECT III® system is packaged with 2 mL and 5 mL of Sterile Water for Injection (sWFI), one Terumo Microbore Infusion set (2 mL only), one full Prescribing Information insert, and one patient insert.1

IU per vial/NDC code.

Prophylaxis

ADVATE dosing for routine prophylaxis1

  • Use dose of 20 to 40 international units of factor VIII per kg of body weight every other day (3 to 4 times weekly).
  • Alternatively, use every third day dosing regimen targeted to maintain factor VIII trough levels ≥1%.
  • Adjust dose based on the patient’s clinical response.
Encourage your patients to track their ADVATE infusions
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How is ADVATE reconstituted?
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On-Demand

ADVATE dosing for
on-demand management1

The goal of treatment is to maintain a plasma factor VIII activity level at or above the plasma levels (in % of normal or in IU/dL) outlined in the table below.

Type of bleeding episodes Minor Moderate§ Major
FVIII level required (% of normal or IU/dL) 20-40 30-60 60-100
Dose (IU/kg) 10-20 15-30 30-50
Frequency of doses (hrs) for patients 6 and older 12-24 12-24 8-24
Frequency of doses (hrs) for patients under 6 8-24 8-24 6-12
Duration of therapy (days) Until the bleeding is resolved (approximately 1 to 3 days) Until the bleeding is resolved (approximately 3 days or more) Until the bleeding is resolved
Type of bleeding episodes FVIII level required
(% of normal or IU/dL)
Dose (IU/kg) Frequency of doses (hours)
for patients 6 and older
Frequency of doses (hours)
for patients under 6
Duration of therapy (days)
Minor 20-40 10-20 12-24 8-24 Until the bleeding is resolved (approximately 1 to 3 days)
Moderate§ 30-60 15-30 12-24 8-24 Until the bleeding is resolved (approximately 3 days or more)
Major 60-100 30-50 8-24 6-12 Until bleeding is resolved

How to calculate the dose

Dose (IU/kg) = Desired factor VIII rise (IU/dL or % of normal) x 0.5 (IU/kg per IU/dL). Please see full Prescribing Information for additional details on dosing.

Minor bleeds include: Early hemarthrosis, mild muscle bleeding, or mild oral bleeding episode

§Moderate bleeds include: Muscle bleeding, bleeding into the oral cavity, definite hemarthrosis, and known trauma

Major bleeds include: Significant gastrointestinal bleeding, intracranial, intra-abdominal or intrathoracic bleeding, central nervous system bleeding, bleeding in the retropharyngeal or retroperitoneal spaces or iliopsoas sheath, fractures, and head trauma

Surgical

ADVATE dosing for
perioperative management1

The goal of treatment is to maintain a plasma factor VIII activity level at or above the plasma level (in % of normal or in IU/dL) outlined in the table below.

Type of surgery Minor
Including tooth extraction
Major
Intracranial, intra-abdominal, or intrathoracic surgery, joint replacement
FVIII level required
(% of normal or IU/dL)
60-100 80-120

(pre- and post-operative)

Dose (IU/kg) 30-50 40-60
Frequency of doses (hours)

Single dose within 1 hour of the operation

12-24 (as needed to control bleeding)

1 dose perioperative to achieve 100% activity

Every 8-24 to keep FVIII activity in desired range. (Every 6-24 hours for patients under the age of 6)

Duration of therapy (days)

Single dose or repeat until bleeding is resolved

For dental procedures, adjunctive therapy may be considered

Until healing is complete

Type of surgery FVIII level required
(% of normal or IU/dL)
Dose (IU/kg) Frequency of doses (hours) Duration of therapy (days)
Minor
Including tooth extraction
60-100 30-50

Single dose within 1 hour of the
operation

12-24 (as needed to control
bleeding)

Single dose or repeat until
bleeding is resolved

For dental procedures,
adjunctive therapy
may be considered

Major
Intracranial, intra-abdominal,
or intrathoracic surgery,
joint replacement
80-120
(pre- and post-operative)
40-60

1 dose perioperative to
achieve 100% activity

Every 8-24 to keep FVIII
activity in desired range.
(Every 6-24 hours for patients
under the age of 6)

Until healing is complete

How to calculate the dose

Dose (IU/kg) = Desired factor VIII rise (IU/dL or % of normal) x 0.5 (IU/kg per IU/dL). Please see full Prescribing Information for additional details on dosing.

How is ADVATE reconstituted?
Discover BAXJECT III benefits
myPKFiT® can help personalize prophylaxis
Learn more
  1. Advate. Prescribing information. Baxalta US Inc; 2018.
  2. Takeda data on file.