For U.S. Healthcare Professionals

myPKFIT

PERSONALIZE TREATMENT FOR YOUR PATIENTS ON ADVATE® PROPHYLAXIS1

myPKFiT for ADVATE is the first and only FDA-approved pharmacokinetic (PK) dosing software for patients 16 and older with hemophilia A. It enables you to personalize prophylaxis for your patients on ADVATE.1,2

Personalized treatment for your patients on ADVATE prophylaxis

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Physician software and patient mobile app

HEALTHCARE PROFESSIONAL PK-GUIDED DOSING SOFTWARE

The myPKFiT software estimates PK curves, allowing you to tailor ADVATE dosing and infusion schedules to personalize prophylaxis treatment for your patients.1,2

TARGET TROUGH LEVEL

You can customize the factor VIII (FVIII) target trough level (1-3% above baseline) and myPKFiT adjusts the dose calculation accordingly.

PK-GUIDED DOSING

Choose preset or customized dosing intervals and generate a chart showing the dosing regimen required to maintain target trough.

Healthcare Professional PK-Guided Dosing Calculator
  •   (blue) FVIII level your patient is likely to experience
  •   (red) FVIII level selected by Time Below slider
  •   (green) FVIII level selected by Time Above slider

FACTOR AWARENESS

Hover over the graph to see the estimated FVIII level at any point along the curve.

PATIENT DOSING RESOURCE

Print a PDF to share with your patient and export information into the myPKFiT mobile app.

See data directly from your patients

See data directly from your patients

PATIENT MOBILE APP

Real-time Factor Levels

The myPKFiT mobile app lets patients track estimated factor levels, manage infusion schedules, and stay connected to their physician along the way.3

PATIENT MOBILE APP Real-time Factor Levels

FACTOR METER

Physician software settings gives patients access to current and future FVIII level estimates, so they may be able to adapt their activity decisions accordingly.

Factor meter

INFUSION TRACKER

Patients can log the date, time, and details of their infusions and share the information with you.

Infusion Tracker

myPKFIT
Matthew it's time to infuse.

RED ZONE ALERT

Alerts patients when their estimated FVIII levels are low and they are at highest risk for a bleed.5

References:

  1. myPKFiT for ADVATE user manual; Shire; 2016.
  2. Valentino LA. Considerations in individualizing prophylaxis in patients with haemophilia A. Haemophilia. 2014;20:607-615.
  3. Alvarez-Roman MT, Fernandez-Bello I, De La Corte-Rodriguez H,et al. Experience of tailoring prophylaxis using factor VIII pharmacokinetic parameters estimated with myPKFiT® in patients with severe haemophilia A without inhibitors. Haemophilia. 2017;23:e33-e57.
  4. myPKFiT mobile application user guide; Shire; 2016.
  5. Collins PW, Blanchette VS, Fischer K, et al. Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. J Thromb Haemost. 2009;7:413-420.