BAXJECT II and BAXJECT III Infusion Systems are designed to make reconstitution of ADVATE [Octocog alfa (Recombinant Coagulation Factor VIII)] quick and easy
BAXJECT III is a reconstitution system
Reconstitute ADVATE in 3 simple steps1
Reconstitute ADVATE in 3 simple steps1
- No assembly required, and 1 step to activate1
- Available in a wide range of dose options — 250 IU to 3000 IU*1
Find the most suitable vial size for each patient*1
The same infusion rate (maximum of 10 ml/minute) can be used with the 2 ml or 5 ml volume.
*Colour of labels and packaging, and the number of potencies, may vary by market.
reconstitution with the baxject iii system
How is ADVATE reconstituted with the BAXJECT III System?
ADVATE is to be administered intravenously after reconstitution of the product.
The reconstituted solution should be inspected visually for any foreign particulate matter and/or discolouration.
After reconstitution the solution should be clear, colourless, and free from foreign particles.
Do not use solutions that are cloudy or have deposits.
- For administration, the use of a luer-lock syringe is required
- Use within 3 hours after reconstitution
- Do not refrigerate the preparation after reconstitution
- Any unused medicinal product or waste material should be disposed of in accordance with local requirements
Reconstitution with the BAXJECT III System
Do not use if the lid is not completely sealed on the blister.
- If the product is still stored in a refrigerator, take the sealed blister (contains powder and solvent vials preassembled with the system for reconstitution) from the refrigerator and let it reach room temperature (between 15°C and 25°C).
- Wash hands thoroughly using soap and warm water.
- Open the ADVATE package by peeling away the lid. Remove the BAXJECT III System from the blister.
- Place the ADVATE on a flat surface with the solvent vial on top (Fig. 1). The solvent vial has a blue stripe. Do not remove the blue cap until instructed in a later step.
- With one hand holding the ADVATE in the BAXJECT III System, press down firmly on the solvent vial with the other hand until the system is fully collapsed and the solvent flows down into the ADVATE vial (Fig. 2). Do not tilt the system until the transfer is complete.
- Verify that the solvent transfer is complete. Swirl gently until all material is dissolved (Fig. 3). Be sure that the ADVATE powder is completely dissolved, otherwise not all reconstituted solution will pass through the device filter. The product dissolves rapidly (usually in less than 1 minute). After reconstitution the solution should be clear, colourless, and free from foreign particles.
ADVATE with BAXJECT III System demonstration and troubleshooting videos
The following videos provide detailed instructions on how to properly use the BAXJECT III System.
baxject iii is quick and easy! I often have to infuse the boys before they leave for school. Saving even those few seconds it would take to mix factor makes a huge diference.
— heidi, mother of 2 boys taking advate prophylaxis since 2005
Actual patients with haemophilia A. Individual results may vary.
BAXJECT II is a needleless transfer device for reconstitution
The BAXJECT II device is intended for use with a single vial of product and is for single use only. Therefore, reconstitution and withdrawing a second vial into the syringe requires a second BAXJECT II device.
Find the most suitable vial size for each patient*†1
The same infusion rate (maximum of 10 ml/minute) can be used with the 2 ml or 5 ml volume.‡
*The number of solvent volume offerings varies by market. 2 ml solvent volume is available with ADVATE vials up to 1500 IU; usage may vary by market. Calculation based on reduction of solvent volume from 5 ml to 2 ml.
†Colour of labels and packaging, and the number of potencies, may vary by market.
‡Infusion time could be reduced using the maximum infusion rate of 10 ml/minute (30 seconds to infuse 5 ml vs 12 seconds to infuse 2 ml). This infusion time does not include the time needed to reconstitute and withdraw the ADVATE dose or prepare the injection site.1