ADVATE Prophylaxis ADVATE Prophylaxis

A goal of zero bleeds

Prophylaxis is the standard of care for people with severe haemophilia in many countries and is recommended as the standard of care by the World Federation of Hemophilia.1 The goal of prophylaxis is to2:

Haemophilic Arthropathy Haemophilic Arthropathy

Even a few bleeds may lead to long-term joint damage3,4

Repeated bleeding into joints is a major cause of morbidity and leads to clinically significant haemophilic arthropathy.2

The World Federation of Hemophilia (WFH) advises that prophylaxis prevents bleeding and joint destruction and should be the goal of therapy to preserve normal musculoskeletal function.1

One size does not fit all

One size does NOT fit all5

There can be a considerable range in how long it takes 2 different individuals to reach a specified trough level, even if they are the same age and weight, which may lead to uncertainty in bleed risk.

Personalize treatment. Know Your Patient's PK Curve

Prophylaxis should be personalised to fit each individual’s needs...5,6 because every individual is unique.6

  • Go beyond weight-based dosing
  • Consider the rate at which the individual's body processes factor VIII

pk varies by individual

PK=Pharmacokinetics

Possible variance5 (Aged 10-65 years; single dose of 30 IU/kg)

Haemophilia PK varies by individual

Personalised dosing considers an individual’s profile to guide treatment decisions.5,6